Anthony E. Spencer II (born January 23, 1984 in Fort Wayne, Indiana, United States) is an American football linebacker and defensive end for the Dallas Cowboys of the National Football League. He was drafted by the Cowboys 26th overall in the 2007 NFL Draft. He played college football at Purdue.
Spencer spent the 2002 season on the Purdue scout team as a redshirt freshman. He appeared in ten games during the 2003 season, recording six tackles and one stop behind the line of scrimmage.
In 2004, Spencer played in 12 games and started in 11. He registered 33 tackles and finished third on the team with 7.5 sacks and 9.5 stops for losses. He also batted down six passes and forced three fumbles, earning All-Big Ten Conference honorable mention.