Guillaume Depardieu (April 7, 1971 – October 13, 2008) was a French actor.
Depardieu was the son of the actor Gérard Depardieu and the actress Elisabeth Depardieu. He was the brother of the actress Julie Depardieu and half-brother of Roxane and Jean Depardieu.
In 1995 Depardieu had a motorcycle accident due to a suitcase that fell off a vehicle in front of him. Depardieu needed surgery on his knee. In the hospital he acquired a Staphylococcus aureus infection in the knee, which led to an amputation in 2003.